Fancc Gene Summary [Rat]
Predicted to be involved in cellular response to oxidative stress and nucleotide-excision repair. Predicted to act upstream of or within several processes, including brain morphogenesis; neuronal stem cell population maintenance; and removal of superoxide radicals. Located in chromatin. Human ortholog(s) of this gene implicated in several diseases, including Fanconi anemia (multiple); acute myeloid leukemia; aspirin-induced respiratory disease; pancreatic cancer; and pancytopenia. Orthologous to human FANCC (FA complementation group C). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fancc |
| Official Name | FA complementation group C [Source:RGD Symbol;Acc:2593] |
| Ensembl ID | ENSRNOG00000016889 |
| Bio databases IDs | |
| Aliases | FA complementation group C |
| Synonyms | FA3, FAC, FACC, FA complementation group C, Fanconi anaemia, complementation group C, Fanconi anemia, complementation group C, LOC103694020 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fancc often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Fanconi anaemia group C protein
- protein binding
Pathways
Biological processes and signaling networks where the Fancc gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial neoplasia
- ovarian cancer
- atrial fibrillation
- Fanconi anemia, group C
- Fanconi anemia
- esophageal squamous cell carcinoma
- esophageal squamous cell cancer
- hereditary cancer-predisposing syndrome
- cancer
role in cell
- cell death
- apoptosis
- cell viability
- quantity
- number
- proliferation
- expression in
- survival
- transcription in
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- chromatin fraction
- membrane fraction
- Cytoplasm
- cytosol
- nuclear foci
- nucleoplasm
- nuclear matrix
- chromatin
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fancc gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- germ cell development
- DNA repair
- macromolecular complex assembly
- removal of superoxide radicals
- cellular response to oxidative stress
- nucleotide-excision repair
- myeloid cell homeostasis
- brain morphogenesis
- neuronal stem cell maintenance
Cellular Component
Where in the cell the gene product is active
- nucleus
- Fanconi anaemia nuclear complex
- cytoplasm
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding