Preb Gene Summary [Rat]
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in COPII vesicle coating and positive regulation of transcription by RNA polymerase II. Is active in endoplasmic reticulum membrane. Orthologous to human PREB (prolactin regulatory element binding). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Preb |
| Official Name | prolactin regulatory element binding [Source:RGD Symbol;Acc:61929] |
| Ensembl ID | ENSRNOG00000007141 |
| Bio databases IDs | |
| Aliases | prolactin regulatory element binding |
| Synonyms | FLJ11114, mSec12, prolactin regulatory element binding, SEC12 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Preb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- WD40 repeats
- double-stranded DNA binding
- nucleic acid binding
- guanyl-nucleotide exchange factor
- enzyme binding
- WD40
- protein binding
- sequence-specific DNA binding
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Preb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ER to Golgi vesicle-mediated transport
- lipoprotein transport
- COPII vesicle coating
- regulation of COPII vesicle coating
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nucleus
- membrane
- endoplasmic reticulum exit site
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- GTPase binding
- guanyl-nucleotide exchange factor activity