Preb Gene Summary [Mouse]
Enables GTPase binding activity and guanyl-nucleotide exchange factor activity. Predicted to be involved in COPII vesicle coating; positive regulation of transcription by RNA polymerase II; and regulation of COPII vesicle coating. Predicted to be located in nucleus. Predicted to be active in endoplasmic reticulum exit site and endoplasmic reticulum membrane. Is expressed in several structures, including central nervous system; embryo mesenchyme; jaw; metanephros; and surface ectoderm. Orthologous to human PREB (prolactin regulatory element binding). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Preb |
| Official Name | prolactin regulatory element binding [Source:MGI Symbol;Acc:MGI:1355326] |
| Ensembl ID | ENSMUSG00000045302 |
| Bio databases IDs | |
| Aliases | prolactin regulatory element binding |
| Synonyms | FLJ11114, mSec12, prolactin regulatory element binding, SEC12 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Preb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- WD40 repeats
- double-stranded DNA binding
- nucleic acid binding
- guanyl-nucleotide exchange factor
- enzyme binding
- WD40
- protein binding
- sequence-specific DNA binding
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Preb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ER to Golgi vesicle-mediated transport
- lipoprotein transport
- COPII vesicle coating
- regulation of COPII vesicle coating
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nucleus
- membrane
- endoplasmic reticulum exit site
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- GTPase binding
- guanyl-nucleotide exchange factor activity