PREB Gene Summary [Human]
This gene encodes a protein that specifically binds to a Pit1-binding element of the prolactin (PRL) promoter. This protein may act as a transcriptional regulator and is thought to be involved in some of the developmental abnormalities observed in patients with partial trisomy 2p. This gene overlaps the abhydrolase domain containing 1 (ABHD1) gene on the opposite strand. [provided by RefSeq, Jul 2008]
Details
| Type | Retained Intron |
| Official Symbol | PREB |
| Official Name | prolactin regulatory element binding [Source:HGNC Symbol;Acc:HGNC:9356] |
| Ensembl ID | ENSG00000138073 |
| Bio databases IDs | |
| Aliases | prolactin regulatory element binding |
| Synonyms | FLJ11114, mSec12, prolactin regulatory element binding, SEC12 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PREB often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- WD40 repeats
- double-stranded DNA binding
- nucleic acid binding
- guanyl-nucleotide exchange factor
- enzyme binding
- WD40
- protein binding
- sequence-specific DNA binding
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PREB gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ER to Golgi vesicle-mediated transport
- lipoprotein transport
- COPII vesicle coating
- regulation of COPII vesicle coating
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nucleus
- membrane
- endoplasmic reticulum exit site
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- GTPase binding
- guanyl-nucleotide exchange factor activity