Atp5mc1 Gene Summary [Rat]
Enables ligand-gated channel activity. Involved in several processes, including cellular response to L-glutamate; cold acclimation; and negative regulation of mitochondrial membrane potential. Located in distal axon and neuronal cell body. Part of proton-transporting ATP synthase complex. Orthologous to human ATP5MC1 (ATP synthase membrane subunit c locus 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atp5mc1 |
| Official Name | ATP synthase membrane subunit c locus 1 [Source:RGD Symbol;Acc:61933] |
| Ensembl ID | ENSRNOG00000007235 |
| Bio databases IDs | |
| Aliases | ATP synthase membrane subunit c locus 1 |
| Synonyms | ATP5A, ATP5G, ATP5G1, ATP9C, ATP synthase membrane subunit c locus 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Atp5mc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATP synthase subunit C
- PRK13469
- mitochondrial presequence
- adenosine-tetraphosphatase
- channel/pore class transporter
- ATP synthase, membrane-bound Fo/Vo/Ao complexes, subunit c
- protein binding
- transporter
- hydrogen ion channel
Pathways
Biological processes and signaling networks where the Atp5mc1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- coronary artery disease
- lichen planus
regulates
- reactive oxygen species
- adenosine triphosphate
- H+
role in cell
- growth
- response by
- extension
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial membrane
- mitochondrial matrix
- mitochondrial inner membrane
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Atp5mc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ATP synthesis coupled proton transport
Cellular Component
Where in the cell the gene product is active
- mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
- mitochondrion
- mitochondrial inner membrane
- mitochondrial proton-transporting ATP synthase complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- hydrogen ion transmembrane transporter activity
- lipid binding