Atp2a3 Gene Summary [Rat]
Enables P-type calcium transporter activity and calcium-dependent ATPase activity. Involved in calcium ion transmembrane transport; endoplasmic reticulum calcium ion homeostasis; and liver regeneration. Predicted to be located in organelle membrane and sarcoplasmic reticulum. Predicted to be active in membrane. Biomarker of hypertension. Orthologous to human ATP2A3 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atp2a3 |
| Official Name | ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 [Source:RGD Symbol;Acc:2175] |
| Ensembl ID | ENSRNOG00000017912 |
| Bio databases IDs | |
| Aliases | ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 |
| Synonyms | ATP2A3 isoform D, ATPase, Ca++ transporting, ubiquitous, ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3, Calcium pump 3, SERCA3, SERCA3 6.5 kb, SERCA3 8 kb, SERCA3 9 kb, SERCA3b, SERCAPLIM430 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Atp2a3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- magnesium-translocating P-type ATPase
- Cation transporter/ATPase, N-terminus
- sarco/endoplasmic reticulum calcium-translocating P-type ATPase
- heavy metal translocating P-type ATPase
- caspase activator
- E1-E2 ATPase
- plasma-membrane proton-efflux P-type ATPase
- copper-(or silver)-translocating P-type ATPase
- plasma-membrane calcium-translocating P-type ATPase
- ion channel binding
- Na,H/K antiporter P-type ATPase alpha subunit
- potassium and/or sodium efflux P-type ATPase, fungal-type
- Cation transport ATPase (P-type)
- Cation transporting ATPase, C-terminus
- Ca2+-transporting ATPase
- calcium ion transporter
- heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase
- golgi membrane calcium-translocating P-type ATPase
- protein binding
- P-type ATPase of unknown pump specificity (type V)
- ATPase, P-type (transporting), HAD superfamily, subfamily IC
- calcium channel regulator
- K+-transporting ATPase, B subunit
- Haloacid Dehalogenase-like Hydrolases
- transporter
Pathways
Biological processes and signaling networks where the Atp2a3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- Parkinson disease
- mixed cardiomyopathy
- spontaneous hypertension
- idiopathic dilated cardiomyopathy
- human papilloma virus infection
- oral cancer
- rebleeding
- spinocerebellar ataxia type 7
regulated by
- 4-phenylbutyric acid
- valproic acid
- vanadate
- Caco2 cells
- ionomycin
- tributyrin
- tetradecanoylphorbol acetate
- nifetepimine
- pioglitazone
- insulin
role in cell
- aggregation
- retention in
- adhesion
- inhibition in
- activity
- secretion
- formation by
- mobilization in
- homeostasis in
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- cellular membrane
- sarcoplasmic reticulum
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum membrane
- nucleoplasm
- nuclear envelope
- intercalated disks
- microsomal membrane
- endoplasmic reticulum-rich vesicle fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Atp2a3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ion transmembrane transport
- calcium ion transport
- negative regulation of receptor binding
- calcium ion transmembrane transport
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
- activation of cysteine-type endopeptidase activity involved in apoptotic process
- cellular calcium ion homeostasis
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nuclear membrane
- sarcoplasmic reticulum
- platelet dense tubular network membrane
- membrane
- endoplasmic reticulum
- organelle membrane
- sarcoplasmic reticulum membrane
Molecular Function
What the gene product does at the molecular level
- calcium-dependent ATPase activity
- ATPase activity
- ATP binding
- protein binding
- metal ion binding
- calcium ion transmembrane transporter activity
- ion channel binding
- calcium-transporting ATPase activity
- cysteine-type endopeptidase activator activity involved in apoptotic process