Tbp Gene Summary [Rat]
Enables DNA binding activity. Contributes to RNA polymerase II general transcription initiation factor activity. Involved in positive regulation of DNA-templated transcription and spermatogenesis. Part of transcription factor TFIID complex. Human ortholog(s) of this gene implicated in late onset Parkinson's disease; schizophrenia; spinocerebellar ataxia type 17; and type 1 diabetes mellitus. Orthologous to human TBP (TATA-box binding protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tbp |
| Official Name | TATA box binding protein [Source:RGD Symbol;Acc:67398] |
| Ensembl ID | ENSRNOG00000001489 |
| Bio databases IDs | |
| Aliases | TATA box binding protein |
| Synonyms | GTF2D, GTF2D1, HDL4, SCA17, TATA-box binding protein, TATA BOX FACTOR, TBP1, TFIID |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tbp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- core domain, structural
- activation domain
- transcription regulator
- inhibitory DNA-binding domain
- DNA binding domain
- nucleic acid binding
- enzyme binding
- transcription factor binding
- protein binding
- general RNA polymerase II transcription factor
- phosphotyrosine binding domain
- sequence-specific DNA binding
- core domain, functional
- DNA binding
- aryl hydrocarbon receptor binding
- double-stranded DNA binding
- n-terminal repeat
- polyglutamine repeat
- p53-binding domain
- TBP_TLF
Pathways
Biological processes and signaling networks where the Tbp gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- Huntington disease
- epithelial cancer
- spinocerebellar ataxia 17
- ataxia
- liver cancer
- motor dysfunction
- COVID-19
- global developmental delay
- neurodegeneration
role in cell
- expression in
- phosphorylation in
- growth
- activation in
- morphology
- degeneration
- transcription in
- destabilization in
- aggregation
- shutdown
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- detergent-insoluble fractions
- nucleolar fraction
- aggregate
- Cytoplasm
- cytosol
- chromosome
- nucleoplasm
- pronucleus
- chromatin
- perikaryon
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tbp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA transcription from RNA polymerase II promoter
- RNA polymerase I transcriptional preinitiation complex assembly
- RNA polymerase II transcriptional preinitiation complex assembly
- transcription from RNA polymerase III promoter
- positive regulation of transcription initiation from RNA polymerase II promoter
- spermatogenesis
- transcription from RNA polymerase II promoter
- transcription initiation, DNA-dependent
- transcription initiation from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- transcription factor TFIIA complex
- chromatin
- nucleoplasm
- male germ cell nucleus
- female germ cell nucleus
- RNA polymerase transcription factor SL1 complex
- nucleus
- euchromatin
- male pronucleus
- transcription factor TFIID complex
- cytoplasm
- macromolecular complex
- female pronucleus
Molecular Function
What the gene product does at the molecular level
- RNA polymerase II core promoter sequence-specific DNA binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- core RNA polymerase III binding transcription factor activity
- core promoter sequence-specific DNA binding
- RNA polymerase I CORE element sequence-specific DNA binding
- protein binding
- aryl hydrocarbon receptor binding
- general RNA polymerase II transcription factor activity
- TFIIB-class transcription factor binding
- RNA polymerase II basal transcription factor binding
- enzyme binding