Col27a1 Gene Summary [Rat]
Predicted to be an extracellular matrix structural constituent conferring tensile strength. Predicted to be involved in extracellular matrix organization and skeletal system development. Predicted to act upstream of or within growth plate cartilage chondrocyte development. Predicted to be located in extracellular region. Predicted to be part of fibrillar collagen trimer. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Orthologous to human COL27A1 (collagen type XXVII alpha 1 chain). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Col27a1 |
| Official Name | collagen type XXVII alpha 1 chain [Source:RGD Symbol;Acc:735115] |
| Ensembl ID | ENSRNOG00000007657 |
| Bio databases IDs | |
| Aliases | collagen type XXVII alpha 1 chain |
| Synonyms | 5730512J02Rik, collagen, type XXVII, alpha 1, collagen type XXVII alpha 1 chain, collagen, type XXVII, α 1, collagen type XXVII α 1 chain, STLS |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Col27a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Family of unknown function (DUF5585)
- Fibrillar collagen C-terminal domain
- LamG
- extracellular matrix structural constituent
- Domain of unknown function (DUF4045)
- Collagen triple helix repeat (20 copies)
- Metaviral_G glycoprotein
Pathways
Biological processes and signaling networks where the Col27a1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- burn
- primary central nervous system lymphoma
- breast cancer
- central nervous system cancer
- lymphomagenesis
- epithelial cancer
- Steel syndrome
- Peyronie disease
- Tourette syndrome
- chronic musculoskeletal pain
role in cell
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- endoplasmic reticulum lumen
- fibrils
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Col27a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- endothelial cell morphogenesis
- skeletal system development
- notochord development
- angiogenesis
- collagen fibril organization
- growth plate cartilage chondrocyte development
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- collagen
- fibrillar collagen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- extracellular matrix structural constituent conferring tensile strength