Rab3d Gene Summary [Rat]
Predicted to enable GTP-dependent protein binding activity; GTPase activity; and myosin V binding activity. Predicted to be involved in bone resorption; exocytosis; and positive regulation of regulated secretory pathway. Predicted to act upstream of or within peptidyl-cysteine methylation and regulation of exocytosis. Predicted to be located in cytoplasmic microtubule and zymogen granule. Predicted to be active in endosome; plasma membrane; and synaptic vesicle. Orthologous to human RAB3D (RAB3D, member RAS oncogene family). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rab3d |
| Official Name | RAB3D, member RAS oncogene family [Source:RGD Symbol;Acc:620924] |
| Ensembl ID | ENSRNOG00000011582 |
| Bio databases IDs | |
| Aliases | RAB3D, member RAS oncogene family |
| Synonyms | C130057E11Rik, D2-2, GOV, RAB16, RAB3D, member RAS oncogene family, RAD3D |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rab3d often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP-dependent protein binding
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- GTPase
- enzyme
- protein binding
- Ras subfamily of RAS small GTPases
- myosin binding
- small GTP-binding protein domain
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- ADP-ribosylation factor
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-small cell lung cancer
- dyspnea
- cyanosis
- infection by Dengue virus 2
role in cell
- proliferation
- apoptosis
- cell viability
- binding
- migration
- size
- morphology
- formation
- association
- exocytosis by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- intracellular space
- cellular membrane
- Plasma Membrane
- secretory granule membrane
- lysosome membrane
- insulin secretory granules
- zymogen granules
- synaptic vesicles
- dense-core vesicles
- secretory vesicles
- cytoplasmic microtubule
- secretory granules
- membrane processes
- perikaryon
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rab3d gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- bone resorption
- exocytosis
- protein secretion
Cellular Component
Where in the cell the gene product is active
- endosome
- extracellular vesicular exosome
- synaptic vesicle
- cytoplasmic microtubule
- zymogen granule
- azurophil granule membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity
- myosin V binding
- GTP-dependent protein binding