C8a Gene Summary [Rat]
Enables complement binding activity. Predicted to be involved in complement activation. Located in extracellular space. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in type I complement component 8 deficiency. Orthologous to human C8A (complement C8 alpha chain). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | C8a |
| Official Name | complement C8 alpha chain [Source:RGD Symbol;Acc:1308355] |
| Ensembl ID | ENSRNOG00000007697 |
| Bio databases IDs | |
| Aliases | complement C8 alpha chain |
| Synonyms | C8 alpha, C8 α, complement C8 alpha chain, complement C8 α chain, complement component 8, alpha polypeptide, complement component 8, α polypeptide |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat C8a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Thrombospondin type 1 repeats
- Thrombospondin type 1 domain
- binding protein
- thrombospondin-1 motif
- membrane-attack complex / perforin
- MAC/Perforin domain
- LDL receptor binding domain
- LDLa
- protein binding
- Spondin-like TSP1 domain
- EGF-like domain
Pathways
Biological processes and signaling networks where the C8a gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic nephropathy
- non-insulin-dependent diabetes mellitus
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- COVID-19
- complement component C8 deficiency type 1
- hepatitis B virus-related hepatocellular carcinoma
- hemolysis
regulates
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cellular membrane
- Plasma Membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat C8a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- complement activation
- complement activation, alternative pathway
- immune response
- complement activation, classical pathway
- killing of cells of other organism
- positive regulation of immune response
Cellular Component
Where in the cell the gene product is active
- membrane attack complex
- extracellular space
- extracellular vesicular exosome
- membrane
- blood microparticle
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- complement binding