Timp2 Gene Summary [Rat]
This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | Timp2 |
| Official Name | TIMP metallopeptidase inhibitor 2 [Source:RGD Symbol;Acc:61312] |
| Ensembl ID | ENSRNOG00000003148 |
| Bio databases IDs | |
| Aliases | TIMP metallopeptidase inhibitor 2 |
| Synonyms | CSC-21K, D11Bwg1104e, DDC8, TIMP metallopeptidase inhibitor 2, tissue inhibitor of metalloproteinase 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Timp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NTR_like
- AB loop
- protease binding
- zinc ion binding
- CD loop
- protease inhibitor
- integrin binding
- protein binding
- enzyme activator activity
- loop domain
- metalloendopeptidase inhibitor
- Tissue inhibitor of metalloproteinase
Pathways
Biological processes and signaling networks where the Timp2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- plasma cell myeloma
- diabetes mellitus
- obesity
- organismal death
- psoriasis
- neoplasia
- preeclampsia
- liver cancer
- liver neoplasia
- digestive system cancer
role in cell
- outgrowth
- growth
- activation in
- expression in
- apoptosis
- phosphorylation in
- survival
- invasion
- activity
- branching
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- secretory granule lumen
- ficolin-1-rich granule lumen
- Cytoplasm
- cell surface
- cell borders
- apical compartment
- organelle lumens
- cellular membrane
- Plasma Membrane
- growth cone
- cytoplasmic vesicles
- extracellular matrix
- brush border
- perikaryon
- plasma
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Timp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to cytokine stimulus
- negative regulation of membrane protein ectodomain proteolysis
- negative regulation of endopeptidase activity
- response to hormone stimulus
Cellular Component
Where in the cell the gene product is active
- extracellular space
- specific granule lumen
- extracellular matrix
- extracellular region
Molecular Function
What the gene product does at the molecular level
- peptidase inhibitor activity
- zinc ion binding
- protein binding
- protease binding
- metalloendopeptidase inhibitor activity