Plod1 Gene Summary [Rat]
Enables several functions, including L-ascorbic acid binding activity; ferrous iron binding activity; and procollagen-lysine 5-dioxygenase activity. Involved in cellular response to hormone stimulus; peptidyl-lysine hydroxylation; and response to hypoxia. Predicted to be located in rough endoplasmic reticulum membrane. Predicted to be part of catalytic complex. Predicted to be active in several cellular components, including Golgi apparatus; collagen-containing extracellular matrix; and endoplasmic reticulum. Biomarker of hypothyroidism. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome kyphoscoliotic type 1. Orthologous to human PLOD1 (procollagen-lysine,2-oxoglutarate 5-dioxygenase 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Plod1 |
| Official Name | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 [Source:RGD Symbol;Acc:621382] |
| Ensembl ID | ENSRNOG00000007763 |
| Bio databases IDs | |
| Aliases | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 |
| Synonyms | 2410042F05Rik, EDS6, EDSKCL1, LH, LH1, LLH, LOC100130069, Lysyl hydroxylase 1, PLOD, procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Plod1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ferrous iron binding
- peptide binding
- vitamin binding
- monosaccharide binding
- binding protein
- GT_LH
- procollagen-lysine 5-dioxygenase
- enzyme
- protein binding
- 2OG-Fe(II) oxygenase superfamily
- Prolyl 4-hydroxylase alpha subunit homologues
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- Ehlers-Danlos syndrome type VI
- familial thoracic aortic aneurysms and dissections
- organismal death
- Ehlers-Danlos syndrome
- aortic dissection
- colorectal cancer
- motor dysfunction or movement disorder
- metastasis
- keratoconus
role in cell
- degradation in
- morphology
- invasion by
- migration
- cell survival
- loss in
- polymerization in
- abnormal morphology
- degeneration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- lysosome
- endoplasmic reticulum membrane
- rough endoplasmatic reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Plod1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to hypoxia
- protein O-linked glycosylation
- peptidyl-lysine hydroxylation
- epidermis development
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- extracellular vesicular exosome
- rough endoplasmic reticulum membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- L-ascorbic acid binding
- protein binding
- iron ion binding
- procollagen-lysine 5-dioxygenase activity
- procollagen glucosyltransferase activity