Ahnak Gene Summary [Rat]
Predicted to enable S100 protein binding activity; identical protein binding activity; and structural molecule activity conferring elasticity. Predicted to be involved in regulation of RNA splicing and regulation of voltage-gated calcium channel activity. Predicted to be located in several cellular components, including costamere; extracellular exosome; and sarcolemma. Predicted to be part of plasma membrane protein complex. Predicted to be active in cytoplasm and nucleus. Used to study autoimmune disease. Orthologous to human AHNAK (AHNAK nucleoprotein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ahnak |
| Official Name | AHNAK nucleoprotein [Source:RGD Symbol;Acc:619779] |
| Ensembl ID | ENSRNOG00000057569 |
| Bio databases IDs | |
| Aliases | AHNAK nucleoprotein |
| Synonyms | 1110004P15RIK, 2310047C17RIK, AHNAK 1, AHNAK nucleoprotein, AHNAKRS, AHNK, DA, desmoyokin, DY6, FLJ33834, Hypothetical PDZ Domain, LOC686579, MGC5395, PM227, RGD1308572, UV118 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ahnak often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- canonical PDZ domain
- protein binding
- PDZ domain
- cpPDZ_Deg_HtrA-like
- structural molecule
- identical protein binding
- AsmA family
- central repeat domain
Pathways
Biological processes and signaling networks where the Ahnak gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hyperplasia
- COVID-19
- Alzheimer disease
- obesity
- aortic valve calcification
- preeclampsia
- Hutchinson-Gilford progeria syndrome
- limb-girdle muscular dystrophy type 1c
- cutaneous melanoma
- cutaneous melanoma cancer
role in cell
- migration
- formation
- formation in
- invasion by
- expression in
- activation
- apoptosis
- growth
- cell viability
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- membrane fraction
- Cytoplasm
- actin cytoskeleton
- Plasma Membrane
- vesicles
- costameres
- intercellular junctions
- cytoplasmic particles
- cytosol
- intercalated disks
- sarcolemma
- Z line
- cytoplasmic vesicles
- transverse tubules
- membrane rafts
- pseudopodia
- exosomes
- nuclear-myofibrillar fraction
- vesicle fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ahnak gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of RNA splicing
Cellular Component
Where in the cell the gene product is active
- costamere
- lysosomal membrane
- plasma membrane
- nucleus
- T-tubule
- cell-cell contact zone
- extracellular vesicular exosome
- focal adhesion
- cytoplasm
- sarcolemma
- membrane
- membrane raft
- actin cytoskeleton
- vesicle
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- cadherin binding
- S100 protein binding