Cox4i2 Gene Summary [Rat]
Predicted to enable cytochrome-c oxidase activity. Involved in cellular response to hypoxia. Predicted to be located in mitochondrial membrane. Predicted to be part of respiratory chain complex IV. Orthologous to human COX4I2 (cytochrome c oxidase subunit 4I2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cox4i2 |
| Official Name | cytochrome c oxidase subunit 4i2 [Source:RGD Symbol;Acc:69422] |
| Ensembl ID | ENSRNOG00000007827 |
| Bio databases IDs | |
| Aliases | cytochrome c oxidase subunit 4i2 |
| Synonyms | COX4, COX4-2, COX4B, COX4L2, COXIV-2, cytochrome c oxidase subunit 4I2, dJ857M17.2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cox4i2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytochrome-c oxidase
- Cyt_c_Oxidase_IV
- enzyme
Pathways
Biological processes and signaling networks where the Cox4i2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial membrane
- mitochondrial intermembrane space
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cox4i2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- generation of precursor metabolites and energy
- mitochondrial electron transport, cytochrome c to oxygen
- cellular respiration
Cellular Component
Where in the cell the gene product is active
- mitochondrial respiratory chain complex IV
Molecular Function
What the gene product does at the molecular level
- cytochrome-c oxidase activity