Cidec Gene Summary [Rat]
Predicted to enable lipid transfer activity; molecular condensate scaffold activity; and phospholipid binding activity. Predicted to be involved in several processes, including execution phase of apoptosis; lipid droplet fusion; and negative regulation of lipid metabolic process. Predicted to act upstream of or within apoptotic process. Predicted to be located in cytosol. Predicted to be active in lipid droplet. Human ortholog(s) of this gene implicated in familial partial lipodystrophy type 5. Orthologous to human CIDEC (cell death inducing DFFA like effector c). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cidec |
| Official Name | cell death-inducing DFFA-like effector c [Source:RGD Symbol;Acc:1562113] |
| Ensembl ID | ENSRNOG00000009153 |
| Bio databases IDs | |
| Aliases | cell death-inducing DFFA-like effector c |
| Synonyms | Adipoocyte-specific, cell death-inducing DFFA-like effector c, CIDE-3, FPLD5, FSP27 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cidec often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid transporter
- phospholipid binding
- binding protein
- CIDE-N domain
- protein binding activity, bridging
- CIDE_N
- protein binding
- phosphatidylinositol binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Ullrich congenital muscular dystrophy
- diabetic nephropathy
- obesity
- insulin resistance
- cardiac fibrosis
- hepatic steatosis
- familial partial lipodystrophy type 5
- aortic valve calcification
- adult-onset obesity
- myocardial hypertrophy
role in cell
- expression in
- growth
- apoptosis
- phosphorylation in
- number
- activation in
- activity
- formation
- accumulation
- enlargement
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- lipid droplets
- cytosol
- lipid droplet contact site
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cidec gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid storage
- apoptotic process
- lipid particle organization
- regulation of apoptotic process
- negative regulation of triglyceride metabolic process
- execution phase of apoptosis
- negative regulation of lipid catabolic process
Cellular Component
Where in the cell the gene product is active
- lipid particle
- nucleus
- cytosol
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding
- phosphatidic acid binding