Tmed10 Gene Summary [Rat]
Predicted to enable protein transmembrane transporter activity and syntaxin binding activity. Involved in several processes, including Golgi organization; response to alkaloid; and vesicle targeting, to, from or within Golgi. Located in several cellular components, including Golgi apparatus; cytoplasmic vesicle; and endoplasmic reticulum-Golgi intermediate compartment. Part of gamma-secretase complex. Orthologous to human TMED10 (transmembrane p24 trafficking protein 10). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tmed10 |
| Official Name | transmembrane p24 trafficking protein 10 [Source:RGD Symbol;Acc:620970] |
| Ensembl ID | ENSRNOG00000007901 |
| Bio databases IDs | |
| Aliases | transmembrane p24 trafficking protein 10 |
| Synonyms | 1110014C03Rik, p23, p24d1, P24(DELTA), p24 delta1, P24(δ), S31I125, S31III125, TMP21, Tmp-21-I, transmembrane p24 trafficking protein 10 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tmed10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein carrier
- binding protein
- cytoplasmic domain
- coatomer-binding domain
- protein binding
- emp24/gp25L/p24 family/GOLD
- sorting signal domain
- transporter
- syntaxin binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Parkinson disease
- prostate cancer
- coronary artery disease
- Alzheimer disease
- aortic valve calcification
role in cell
- apoptosis
- growth
- binding
- activation in
- abnormal morphology
- differentiation
- retention in
- organization
- trafficking in
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- endoplasmic reticulum fraction
- Golgi-enriched fraction
- membrane fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- perinuclear Golgi regions
- perinuclear region
- membrane surface
- cellular membrane
- Nucleus
- Plasma Membrane
- vesicles
- Golgi Apparatus
- Endoplasmic Reticulum
- secretory granule membrane
- ER-to-Golgi intermediate compartment
- endoplasmic reticulum membrane
- Golgi membrane
- cis Golgi networks
- zymogen granules
- synaptic vesicles
- transport vesicles
- cytoplasmic vesicles
- microsomal membrane
- Golgi cisternae
- phagosomes
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tmed10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein transmembrane transport
- retrograde vesicle-mediated transport, Golgi to ER
- Golgi organization
- COPI coating of Golgi vesicle
- intracellular protein transport
- COPII vesicle coating
- vesicle targeting, to, from or within Golgi
- ER to Golgi vesicle-mediated transport
- regulated secretory pathway
- cargo loading into vesicle
- positive regulation of protein secretion
- positive regulation of interleukin-1 production
- COPI-coated vesicle budding
Cellular Component
Where in the cell the gene product is active
- trans-Golgi network transport vesicle
- endoplasmic reticulum
- Golgi membrane
- Golgi apparatus
- endoplasmic reticulum-Golgi intermediate compartment
- zymogen granule membrane
- plasma membrane
- endoplasmic reticulum membrane
- secretory granule membrane
- cis-Golgi network
- melanosome
- ER to Golgi transport vesicle membrane
- membrane
- gamma-secretase complex
- ER to Golgi transport vesicle
- transport vesicle
- endoplasmic reticulum-Golgi intermediate compartment membrane
- COPI-coated vesicle
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein transmembrane transporter activity
- syntaxin binding
- cargo receptor activity