Cldn18 Gene Summary [Rat]
Predicted to enable structural molecule activity. Involved in response to ethanol. Predicted to be located in tight junction. Predicted to be active in bicellular tight junction and plasma membrane. Orthologous to human CLDN18 (claudin 18). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cldn18 |
| Official Name | claudin 18 [Source:RGD Symbol;Acc:1359696] |
| Ensembl ID | ENSRNOG00000030386 |
| Bio databases IDs | |
| Aliases | claudin 18 |
| Synonyms | Claudin 18, DKFZP564B2062, LOC100366183, SFTA5, SFTPJ |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cldn18 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PMP-22/EMP/MP20/Claudin family
- extracellular loop
- protein binding
- identical protein binding
Pathways
Biological processes and signaling networks where the Cldn18 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung cancer
- epithelial cancer
- gastroesophageal junction adenocarcinoma
- metastatic gastric adenocarcinoma
- colorectal cancer
- gastric adenocarcinoma
- gastric epithelial cancer
- colon adenocarcinoma
- colon epithelial cancer
- metastatic gastroesophageal junction adenocarcinoma
regulates
- mineral
role in cell
- proliferation
- number
- differentiation
- assembly
- organization
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cellular membrane
- intercellular junctions
- tight junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cldn18 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- calcium-independent cell-cell adhesion
- organ growth
- negative regulation of protein localization to nucleus
- epithelial fluid transport
- cell adhesion
- negative regulation of bone resorption
- cellular response to estrogen stimulus
- lung alveolus development
- response to ethanol
- epithelial cell proliferation
- digestive tract development
- negative regulation of tumor necrosis factor-mediated signaling pathway
- tight junction assembly
- negative regulation of osteoclast development
- protein localization to nucleus
Cellular Component
Where in the cell the gene product is active
- tight junction
- lateral plasma membrane
- cell-cell junction
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- structural molecule activity