Rgs6 Gene Summary [Rat]
Enables protein domain specific binding activity. Involved in positive regulation of neuron differentiation. Part of protein-containing complex. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human RGS6 (regulator of G protein signaling 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rgs6 |
| Official Name | regulator of G-protein signaling 6 [Source:RGD Symbol;Acc:3569] |
| Ensembl ID | ENSRNOG00000008082 |
| Bio databases IDs | |
| Aliases | regulator of G-protein signaling 6 |
| Synonyms | GAP, HA117, regulator of G-protein signaling 6, S914 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rgs6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
- GGL
- Regulator of G-protein signalling DHEX domain
- Regulator of G protein signaling (RGS) domain superfamily
- GTPase
- protein domain specific binding
- GTPase activator
- enzyme
- protein binding
- zDHHC ankyrin repeat binding domain
- GGL domain
- Regulator of G protein signaling domain
- DEP
Pathways
Biological processes and signaling networks where the Rgs6 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- prostate cancer
- psoriasis
- schizophrenia
- COVID-19
- obesity
- tinnitus
- lung squamous cell carcinoma
- squamous cell lung cancer
- major depression
role in cell
- expression in
- differentiation
- apoptosis
- signaling in
- activation in
- generation in
- epithelial-mesenchymal transition
- disruption
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Extracellular Space
- perinuclear region
- cellular membrane
- Nucleus
- Plasma Membrane
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rgs6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of signal transduction
- G-protein coupled receptor signaling pathway
- regulation of G-protein coupled receptor protein signaling pathway
- positive regulation of GTPase activity
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- membrane
- cytosol
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase activity
- GTPase activator activity