Lrrc4 Gene Summary [Mouse]
Involved in modulation of chemical synaptic transmission. Acts upstream of or within excitatory synapse assembly and postsynaptic density protein 95 clustering. Located in dendritic spine; excitatory synapse; and postsynaptic membrane. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density membrane. Is expressed in several structures, including branchial arch; central nervous system; metanephros; sensory organ; and vibrissa. Orthologous to human LRRC4 (leucine rich repeat containing 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lrrc4 |
| Official Name | leucine rich repeat containing 4 [Source:MGI Symbol;Acc:MGI:2182081] |
| Ensembl ID | ENSMUSG00000049939 |
| Bio databases IDs | |
| Aliases | leucine rich repeat containing 4 |
| Synonyms | BAG, leucine rich repeat containing 4, MBAG1, NAG14, NGL-2, NLG-2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lrrc4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Leucine-rich repeats, outliers
- Leucine-rich repeats, typical (most populated) subfamily
- protein phosphatase 1 regulatory subunit 42
- immunoglobulin domain
- Immunoglobulin I-set domain
- Leucine rich repeat
- Leucine rich repeat C-terminal domain
- BspA type Leucine rich repeat region (6 copies)
- protein binding
- Leucine Rich repeats (2 copies)
- cytoplasmic domain
- Immunoglobulin like
- Leucine rich repeat N-terminal domain
- PDZ binding motif
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- androgenic alopecia
- rosacea
- hyperactive behavior
regulated by
- motor neurons
- LMK-235
- 9,10-dimethyl-1,2-benzanthracene
- NTNG2
- formestane
- propylthiouracil
role in cell
- expression in
- proliferation
- phosphorylation in
- activation in
- synaptic transmission
- adhesion
- differentiation
- development
- assembly
- stabilization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- glutaminergic synapse
- cell surface
- cellular membrane
- postsynaptic membrane
- synaptic membrane
- dendritic spines
- neurites
- synapse
- axons
- excitatory synapses
- dendritic branches
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lrrc4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- postsynaptic density protein 95 clustering
- regulation of synaptic transmission
Cellular Component
Where in the cell the gene product is active
- excitatory synapse
- dendritic spine
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding