Cntrob Gene Summary [Rat]
Predicted to enable protein domain specific binding activity. Predicted to be involved in centriole replication; centrosome separation; and mitotic cytokinetic process. Predicted to be located in ciliary basal body and cytosol. Predicted to be active in centriole and centrosome. Used to study male infertility and male infertility due to acephalic spermatozoa. Orthologous to human CNTROB (centrobin, centriole duplication and spindle assembly protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cntrob |
| Official Name | centrobin, centriole duplication and spindle assembly protein [Source:RGD Symbol;Acc:1307488] |
| Ensembl ID | ENSRNOG00000008270 |
| Bio databases IDs | |
| Aliases | centrobin, centriole duplication and spindle assembly protein |
| Synonyms | 9830165K03Rik, Centrobin, centrobin, centriole duplication and spindle assembly protein, centrobin, centrosomal BRCA2 interacting protein, LIP8, LOC102555947, Nip2, PP1221, RGD1307488 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cntrob often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain of unknown function (DUF4659)
- Crescentin protein
- TPR/MLP1/MLP2-like protein
- Autophagy protein 16 (ATG16)
- Ciliary protein causing Leber congenital amaurosis disease
- Trichohyalin-plectin-homology domain
- Family with sequence similarity 184, A and B
- protein domain specific binding
- Intermediate filament protein
- protein binding
- bZIP
- Laminin Domain I
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- daughter centriole
- basal bodies
- centrosome
- centriole
- cytosol
- centrosomal fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cntrob gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- centrosome separation
- centriole replication
Cellular Component
Where in the cell the gene product is active
- centrosome
- cytoplasm
- centriole
Molecular Function
What the gene product does at the molecular level
- protein domain specific binding
- protein binding