CNTROB Gene Summary [Human]
This gene encodes a centrosomal protein that interacts with BRCA2, and is required for centriole duplication and cytokinesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Details
| Type | Protein Coding |
| Official Symbol | CNTROB |
| Official Name | centrobin, centriole duplication and spindle assembly protein [Source:HGNC Symbol;Acc:HGNC:29616] |
| Ensembl ID | ENSG00000170037 |
| Bio databases IDs | |
| Aliases | centrobin, centriole duplication and spindle assembly protein, centrobin |
| Synonyms | 9830165K03Rik, Centrobin, centrobin, centriole duplication and spindle assembly protein, centrobin, centrosomal BRCA2 interacting protein, LIP8, LOC102555947, Nip2, PP1221, RGD1307488 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CNTROB often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain of unknown function (DUF4659)
- Crescentin protein
- TPR/MLP1/MLP2-like protein
- Autophagy protein 16 (ATG16)
- Ciliary protein causing Leber congenital amaurosis disease
- Trichohyalin-plectin-homology domain
- Family with sequence similarity 184, A and B
- protein domain specific binding
- Intermediate filament protein
- protein binding
- bZIP
- Laminin Domain I
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- daughter centriole
- basal bodies
- centrosome
- centriole
- cytosol
- centrosomal fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CNTROB gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- centrosome separation
- centriole replication
Cellular Component
Where in the cell the gene product is active
- centrosome
- cytoplasm
- centriole
Molecular Function
What the gene product does at the molecular level
- protein domain specific binding
- protein binding