Ttk Gene Summary [Rat]
Predicted to enable identical protein binding activity; kinetochore binding activity; and protein kinase activity. Predicted to be involved in negative regulation of metaphase/anaphase transition of cell cycle; protein localization to kinetochore; and repair of mitotic kinetochore microtubule attachment defect. Predicted to act upstream of or within female meiosis chromosome segregation; protein localization to organelle; and protein phosphorylation. Predicted to be located in cytoplasm. Predicted to be active in kinetochore and nucleus. Orthologous to human TTK (TTK protein kinase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ttk |
| Official Name | Ttk protein kinase [Source:RGD Symbol;Acc:1305558] |
| Ensembl ID | ENSRNOG00000029055 |
| Bio databases IDs | |
| Aliases | Ttk protein kinase |
| Synonyms | CT96, ESK, Esk1, MPH1, MPS1, MPS1L1, PYT, TTK protein kinase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ttk often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein threonine/tyrosine kinase
- Protein tyrosine and serine/threonine kinase
- alpha helix
- protein binding
- protein-tyrosine kinase
- Protein kinase domain
- identical protein binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- binding protein
- Protein Kinases, catalytic domain
- alcohol group acceptor phosphotransferase
- tetratricopeptide repeat
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- squamous cell lung cancer
- non-small cell lung cancer
- neoplasia
- metastasis
- epithelial neoplasia
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- gastric cancer
- endometrial adenocarcinoma
role in cell
- expression in
- phosphorylation in
- growth
- proliferation
- apoptosis
- cell death
- signaling in
- invasiveness
- migration
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- spindle apparatus
- Cytoplasm
- centrosome
- chromosome
- kinetochores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ttk gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitotic cell cycle spindle assembly checkpoint
- spindle organization
- mitotic spindle organization
- positive regulation of cell proliferation
- protein localization to kinetochore
- chromosome segregation
- female meiosis chromosome segregation
- peptidyl-serine phosphorylation
- meiotic spindle assembly checkpoint
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- membrane
- spindle
- kinetochore
Molecular Function
What the gene product does at the molecular level
- ATP binding
- kinetochore binding
- protein tyrosine kinase activity
- identical protein binding
- protein serine/threonine/tyrosine kinase activity
- protein binding
- protein serine/threonine kinase activity