Lgals8 Gene Summary [Rat]
Predicted to enable carbohydrate binding activity and integrin binding activity. Predicted to be involved in cellular response to virus; lymphatic endothelial cell migration; and xenophagy. Predicted to act upstream of or within T cell costimulation and plasma cell differentiation. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human LGALS8 (galectin 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lgals8 |
| Official Name | galectin 8 [Source:RGD Symbol;Acc:621272] |
| Ensembl ID | ENSRNOG00000018046 |
| Bio databases IDs | |
| Aliases | galectin 8 |
| Synonyms | 1200015E08Rik, AW742467, D13Ertd524e, Gal-8, Galectin-8, Lectin, lectin, galactose binding, soluble 8, PCTA, PCTA-1, Po66-CBP |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Lgals8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- carbohydrate recognition domain
- integrin binding
- protein binding
- carbohydrate binding
- GLECT
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- breast cancer
- colorectal cancer
- prostate cancer
- metastatic colorectal cancer
- Rett syndrome
- colon cancer
role in cell
- expression in
- apoptosis
- growth
- phosphorylation in
- activation in
- quantity
- adhesion
- differentiation
- substrate adhesion
- cell spreading
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- detergent resistant lipid raft fraction
- Cytoplasm
- cell surface
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Lgals8 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- membrane
- cytosol
- cytoplasmic vesicle
Molecular Function
What the gene product does at the molecular level
- protein binding
- integrin binding
- carbohydrate binding