Eda Gene Summary [Rat]
Predicted to enable cytokine activity; death receptor agonist activity; and death receptor binding activity. Predicted to be involved in animal organ development; cytokine-mediated signaling pathway; and regulation of non-canonical NF-kappaB signal transduction. Predicted to act upstream of or within several processes, including hair follicle placode formation; positive regulation of signal transduction; and trachea gland development. Predicted to be located in several cellular components, including apical part of cell; endoplasmic reticulum membrane; and lipid droplet. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in ectodermal dysplasia 1 and tooth agenesis. Orthologous to human EDA (ectodysplasin A). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Retained Intron |
| Official Symbol | Eda |
| Official Name | ectodysplasin-A [Source:RGD Symbol;Acc:1563178] |
| Ensembl ID | ENSRNOG00000032208 |
| Bio databases IDs | |
| Aliases | ectodysplasin-A |
| Synonyms | ECTD1, Ectodysplasin, ectodysplasin-A, ED1, ED1-A1, ED1-A2, EDA1, EDA2, HED, HED1, ODT1, RGD1563178, STHAGX1, Ta, tabby, TNLG7C, XHED, XLHED |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Eda often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- death receptor binding
- receptor binding domain
- TNF homology domain
- TNF
- receptor agonist activity
- protein binding
- receptor binding
- cytokine
Pathways
Biological processes and signaling networks where the Eda gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Christ-Siemens-Touraine syndrome
- X-linked selective tooth agenesis-1
- ectodermal dysplasia
- oligodontia
- hypodontia
- hereditary disorder
- myodegeneration
- hypohidrotic ectodermal dysplasia
- systemic lupus erythematosus
- neuroticism
role in cell
- number
- apoptosis
- quantity
- phosphorylation in
- expression in
- adhesion
- proliferation
- survival
- atrophy
- transactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- cytoskeleton
- Extracellular Space
- apical compartment
- cellular membrane
- lipid droplets
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Eda gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-matrix adhesion
- salivary gland cavitation
- trachea gland development
- positive regulation of canonical Wnt receptor signaling pathway
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- hair follicle placode formation
- odontogenesis of dentin-containing tooth
- organ development
- immune response
- pigmentation
- positive regulation of gene expression
- cytokine-mediated signaling pathway
- cell differentiation
- gene expression
- canonical Wnt receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- lipid particle
- endoplasmic reticulum membrane
- extracellular space
- cytoskeleton
- apical part of cell
- intracellular membrane-bounded organelle
- collagen
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- tumor necrosis factor receptor binding
- death receptor binding
- cytokine activity
- receptor binding