Gjb3 Gene Summary [Rat]
Predicted to enable gap junction channel activity. Involved in several processes, including cellular response to retinoic acid; in utero embryonic development; and spermatogenesis. Located in gap junction. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 2B; autosomal recessive nonsyndromic deafness 1A; colorectal adenocarcinoma; erythrokeratodermia variabilis; and erythrokeratodermia variabilis et progressiva 1. Orthologous to human GJB3 (gap junction protein beta 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gjb3 |
| Official Name | gap junction protein, beta 3 [Source:RGD Symbol;Acc:2695] |
| Ensembl ID | ENSRNOG00000014372 |
| Bio databases IDs | |
| Aliases | gap junction protein, beta 3 |
| Synonyms | Cnx31, CX31, CXB3, Cxnc, D4Wsu144e, DFNA2, DFNA2B, EKV, EKVP1, Gap junction membrane channel protein beta3, Gap Junction Protein Beta 3, gap junction protein, beta 3, Gap Junction Protein β 3, gap junction protein, β 3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gjb3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Connexin homologues
- Gap junction channel protein cysteine-rich domain
- protein binding
- transporter
- Connexin
Pathways
Biological processes and signaling networks where the Gjb3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- GJB2/GJB3 digenic deafness
- erythrokeratodermia variabilis et progressiva 1
- autosomal dominant deafness with peripheral neuropathy
- autosomal dominant nonsyndromic deafness type 2B
- sensorineural hearing loss
- erythrokeratodermia variabilis
- metastasis
- familial nonsyndromic hearing impairment
- autosomal recessive deafness type 1A
- nonsyndromic hearing impairment
role in cell
- cellular infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell junction
- intracellular membrane-bounded organelle
- Cytoplasm
- cellular membrane
- intercellular junctions
- gap junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gjb3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transmembrane transport
- in utero embryonic development
- cellular response to retinoic acid
- spermatogenesis
- cell-cell signaling
- placenta development
- skin development
Cellular Component
Where in the cell the gene product is active
- gap junction
- connexon complex
- cytoplasm
- intracellular membrane-bounded organelle
- cell junction
Molecular Function
What the gene product does at the molecular level
- protein binding
- gap junction channel activity