Slc22a5 Gene Summary [Rat]
Enables (R)-carnitine transmembrane transporter activity. Involved in (R)-carnitine transmembrane transport and liver regeneration. Located in basolateral plasma membrane and cytosol. Biomarker of chronic obstructive pulmonary disease; congestive heart failure; and metabolic dysfunction-associated steatotic liver disease. Human ortholog(s) of this gene implicated in Crohn's disease; cardiomyopathy; inherited metabolic disorder; and systemic primary carnitine deficiency disease. Orthologous to human SLC22A5 (solute carrier family 22 member 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc22a5 |
| Official Name | solute carrier family 22 member 5 [Source:RGD Symbol;Acc:3702] |
| Ensembl ID | ENSRNOG00000008432 |
| Bio databases IDs | |
| Aliases | solute carrier family 22 member 5 |
| Synonyms | CDSP, CT1, High Affinity Carnitine Transporter, jvs, Lstpl, OCTN2, solute carrier family 22 member 5, solute carrier family 22 (organic cation transporter), member 5, UST2r |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc22a5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- benzoate transport
- sodium ion transporter
- MFS transporter, sugar porter (SP) family
- Major Facilitator Superfamily
- Multidrug resistance protein
- protein binding
- betaine transporter
- PDZ-domain binding
- organic cation transporter
- Sugar (and other) transporter
- carnitine transporter
- cation transport protein
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- asthma
- organismal death
- COVID-19
- primary systemic carnitine deficiency
- hereditary disorder
- presynaptic congenital myasthenic syndrome type 20
- myelodysplastic syndrome
- inflammatory bowel disease
- cardiovascular disorder
role in cell
- cellular infiltration by
- apoptosis
- quantity
- production in
- organization
- metabolism in
- beta-oxidation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cellular membrane
- vesicles
- Endoplasmic Reticulum
- cytosol
- apical membrane
- basolateral membrane
- basal membrane
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc22a5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- quaternary ammonium group transport
- sodium ion transport
- sodium-dependent organic cation transport
- (R)-carnitine transport
- response to interferon-gamma
- response to symbiotic bacterium
- carnitine transport
- positive regulation of intestinal epithelial structure maintenance
- response to tumor necrosis factor
Cellular Component
Where in the cell the gene product is active
- basal plasma membrane
- brush border membrane
- extracellular vesicular exosome
- cytoplasm
- cytosol
- endoplasmic reticulum
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- xenobiotic transporter activity
- ATP binding
- protein binding
- quaternary ammonium group transmembrane transporter activity
- betaine transmembrane transporter activity
- PDZ domain binding
- symporter activity
- carnitine transporter activity