Nbn

Predicted to enable several functions, including histone binding activity; phosphorylation-dependent protein binding activity; and protein serine/threonine kinase activator activity. Involved in several processes, including host-mediated suppression of symbiont invasion; negative regulation of neuron differentiation; and regulation of fibroblast proliferation. Predicted to be located in Golgi apparatus; nucleus; and replication fork. Predicted to be part of BRCA1-C complex and Mre11 complex. Predicted to be active in chromosome, telomeric region and site of double-strand break. Human ortholog(s) of this gene implicated in several diseases, including Nijmegen breakage syndrome; acute lymphoblastic leukemia; aplastic anemia; rectum cancer; and reproductive organ cancer (multiple). Orthologous to human NBN (nibrin). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nbn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Nbn gene in rat plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the rat Nbn gene, providing context for its role in the cell.