Gnpnat1 Gene Summary [Rat]
Enables glucosamine 6-phosphate N-acetyltransferase activity and monosaccharide binding activity. Involved in N-acetylglucosamine metabolic process; glucosamine metabolic process; and liver development. Predicted to be located in Golgi apparatus; endoplasmic reticulum-Golgi intermediate compartment; and late endosome. Orthologous to human GNPNAT1 (glucosamine-phosphate N-acetyltransferase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gnpnat1 |
| Official Name | glucosamine-phosphate N-acetyltransferase 1 [Source:RGD Symbol;Acc:1563144] |
| Ensembl ID | ENSRNOG00000008641 |
| Bio databases IDs | |
| Aliases | glucosamine-phosphate N-acetyltransferase 1 |
| Synonyms | AU017428, EMeg32, FLJ10607, glucosamine-phosphate N-acetyltransferase 1, GNA1, GNPNAT, Gpnat1, Gsnpat, RGD1563144, RHZDAN |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gnpnat1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- glucosamine 6-phosphate N-acetyltransferase
- Acetyltransferase (GNAT) family
- monosaccharide binding
- NAT_SF
- Acetyltransferase (GNAT) domain
- enzyme
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- organismal death
- breast cancer
- growth failure
- HER2 negative hormone receptor negative breast cancer
- spondyloepimetaphyseal dysplasia
- lung adenocarcinoma
- lung adenocarcinoma formation
- hepatocellular carcinoma
role in cell
- proliferation
- adhesion
- apoptosis
- expression in
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- cellular membrane
- vesicles
- Golgi Apparatus
- ER-to-Golgi intermediate compartment
- cytosol
- Golgi membrane
- late endosomes
- Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gnpnat1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- UDP-N-acetylglucosamine biosynthetic process
Cellular Component
Where in the cell the gene product is active
- cytosol
- Golgi membrane
- endosome membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- glucosamine 6-phosphate N-acetyltransferase activity