Cdkn2c Gene Summary [Rat]
Predicted to enable cyclin-dependent protein serine/threonine kinase inhibitor activity and protein kinase binding activity. Involved in oligodendrocyte differentiation. Predicted to be located in cytoplasm and nucleus. Orthologous to human CDKN2C (cyclin dependent kinase inhibitor 2C). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cdkn2c |
| Official Name | cyclin-dependent kinase inhibitor 2C [Source:RGD Symbol;Acc:2325] |
| Ensembl ID | ENSRNOG00000008956 |
| Bio databases IDs | |
| Aliases | cyclin-dependent kinase inhibitor 2C |
| Synonyms | CDKN6, cyclin-dependent kinase inhibitor 2C, INK4C, p18, p18-INK4C, p18-INK6 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cdkn2c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cyclin-dependent protein kinase inhibitor activity
- transcription regulator
- Ankyrin repeats (many copies)
- protein kinase binding
- Ankyrin repeats (3 copies)
- protein binding
- Ankyrin repeat
- ankyrin repeats
Pathways
Biological processes and signaling networks where the Cdkn2c gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- neoplasia
- lymphomagenesis
- hematologic cancer
- lymphoid cancer
- hematological neoplasia
- lymphatic neoplasia
- thoracic cancer
role in cell
- cell cycle progression
- growth
- apoptosis
- proliferation
- expression in
- migration
- cell viability
- differentiation
- number
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cdkn2c gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- oligodendrocyte differentiation
- negative regulation of stem cell proliferation
- negative regulation of cell growth
- negative regulation of cell proliferation
- stem cell proliferation
- regulation of G1/S transition of mitotic cell cycle
- regulation of cyclin-dependent protein kinase activity
- negative regulation of phosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- cyclin-dependent protein kinase inhibitor activity