Nub1 Gene Summary [Rat]
Predicted to be involved in several processes, including positive regulation of proteasomal ubiquitin-dependent protein catabolic process; response to tumor necrosis factor; and response to type II interferon. Predicted to act upstream of or within proteasomal protein catabolic process. Predicted to be located in Lewy body; cytosol; and nuclear lumen. Orthologous to human NUB1 (negative regulator of ubiquitin like proteins 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nub1 |
| Official Name | negative regulator of ubiquitin-like proteins 1 [Source:RGD Symbol;Acc:1359489] |
| Ensembl ID | ENSRNOG00000009282 |
| Bio databases IDs | |
| Aliases | negative regulator of ubiquitin-like proteins 1 |
| Synonyms | 4931404D21Rik, 6330412F12Rik, BS4, Bs4 Peptide, negative regulator of ubiquitin-like proteins 1, NY-REN-18 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nub1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- PEST domain
- Ubl1_cv_Nsp3_N-like
- protein binding
- ubiquitin-like domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- intracellular space
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nub1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to interferon-gamma
- regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- protein ubiquitination
- response to tumor necrosis factor
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- cytosol
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding