Sncaip Gene Summary [Rat]
Predicted to enable identical protein binding activity and ubiquitin protein ligase binding activity. Predicted to be involved in dopamine metabolic process; regulation of inclusion body assembly; and regulation of neurotransmitter secretion. Predicted to be located in cytoplasmic ribonucleoprotein granule and nucleoplasm. Orthologous to human SNCAIP (synuclein alpha interacting protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sncaip |
| Official Name | synuclein, alpha interacting protein [Source:RGD Symbol;Acc:1309283] |
| Ensembl ID | ENSRNOG00000018254 |
| Bio databases IDs | |
| Aliases | synuclein, alpha interacting protein |
| Synonyms | 2810407O15Rik, 4933427B05Rik, Sph1, Synphilin-1, synuclein alpha interacting protein, synuclein, alpha interacting protein, synuclein, alpha interacting protein (synphilin), synuclein α interacting protein, synuclein, α interacting protein, synuclein, α interacting protein (synphilin), SYPH1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sncaip often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- ankyrin binding domain
- transcription regulator
- Ankyrin repeats (many copies)
- Ankyrin repeats (3 copies)
- coiled-coil domain
- protein binding
- Synphilin-1 alpha-Synuclein-binding domain
- identical protein binding
- ankyrin repeats
Pathways
Biological processes and signaling networks where the Sncaip gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- epithelial cancer
- diabetic nephropathy
- liver cancer
- squamous cell cancer
- oligodendroglioma
- glioma formation
- renal cell carcinoma
- renal cell cancer
- melanoma
role in cell
- cell viability
- cell death
- formation
- formation in
- assembly
- degradation in
- aggregation in
- ubiquitination in
- autoubiquitination in
- length
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic ribonucleoprotein granule
- cytosol
- nucleoplasm
- synaptic vesicles
- synaptosomes
- membrane processes
- perikaryon
- presynaptic terminals
- synaptic vesicle fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sncaip gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of neurotransmitter secretion
- dopamine metabolic process
- cell death
- regulation of inclusion body assembly
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- cytoplasm
- synaptic vesicle
- cytosol
- neuronal cell body
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- ubiquitin protein ligase binding
- protein binding