Noxa1 Gene Summary [Rat]
Predicted to enable several functions, including SH3 domain binding activity; small GTPase binding activity; and superoxide-generating NADPH oxidase activator activity. Predicted to be involved in regulation of hydrogen peroxide metabolic process; regulation of respiratory burst; and superoxide anion generation. Predicted to be located in cytoplasm. Predicted to be part of NADPH oxidase complex. Orthologous to human NOXA1 (NADPH oxidase activator 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Noxa1 |
| Official Name | NADPH oxidase activator 1 [Source:RGD Symbol;Acc:1306687] |
| Ensembl ID | ENSRNOG00000009286 |
| Bio databases IDs | |
| Aliases | NADPH oxidase activator 1 |
| Synonyms | NADPH oxidase activator 1, NY-CO-31, p51NOX, SDCCAG31 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Noxa1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- activation domain
- superoxide-generating NADPH oxidase activator
- enzyme binding
- protein binding
- identical protein binding
- tetratricopeptide repeat
- PB1
- SH3-domain binding
- phosphorylation site
- Src Homology 3 domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- adult T-cell leukemia/lymphoma
- mature T-cell neoplasia
- T-cell non-Hodgkin disease
role in cell
- migration
- production in
- activation in
- formation in
- binding in
- generation in
- glycolysis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membranes
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Noxa1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- superoxide metabolic process
- regulation of respiratory burst
- regulation of hydrogen peroxide metabolic process
- superoxide anion generation
Cellular Component
Where in the cell the gene product is active
- NADPH oxidase complex
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- small GTPase binding
- superoxide-generating NADPH oxidase activator activity
- SH3 domain binding
- enzyme binding