Shbg Gene Summary [Rat]
Predicted to enable steroid binding activity. Involved in primary spermatocyte growth. Predicted to be located in extracellular space. Human ortholog(s) of this gene implicated in endometrial cancer and type 2 diabetes mellitus. Orthologous to human SHBG (sex hormone binding globulin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Shbg |
| Official Name | sex hormone binding globulin [Source:RGD Symbol;Acc:3671] |
| Ensembl ID | ENSRNOG00000011357 |
| Bio databases IDs | |
| Aliases | sex hormone binding globulin |
| Synonyms | ABP, Abpa, SBP, sex hormone binding globulin, TEBG |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Shbg often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- LamG
- N-linked glycosylation site
- laminin-type G domain 5 module
- O-linked glycosylation site
- protein binding
- androgen binding
- laminin-type G domain 4 module
- laminin G domain
Pathways
Biological processes and signaling networks where the Shbg gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- metastasis
- acne vulgaris
- obesity
- non-insulin-dependent diabetes mellitus
- polycystic ovary syndrome
- diabetes mellitus
- osteoarthritis
- hepatocellular carcinoma
- liver cancer
role in cell
- activation in
- phosphorylation in
- expression in
- growth
- quantity
- apoptosis
- accumulation
- morphology
- localization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- soluble fraction
- Cytoplasm
- Plasma Membrane
- granules
- cytosol
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Shbg gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- androgen binding
- steroid binding