Itsn1 Gene Summary [Rat]
Predicted to enable kinase activator activity; molecular adaptor activity; and proline-rich region binding activity. Involved in positive regulation of dendritic spine development; positive regulation of transport; and regulation of synapse organization. Located in several cellular components, including clathrin-coated pit; dendrite; and neuronal cell body. Is active in glutamatergic synapse; postsynaptic actin cytoskeleton; and postsynaptic endocytic zone. Orthologous to human ITSN1 (intersectin 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Itsn1 |
| Official Name | intersectin 1 [Source:RGD Symbol;Acc:2935] |
| Ensembl ID | ENSRNOG00000002001 |
| Bio databases IDs | |
| Aliases | intersectin 1 |
| Synonyms | AI839402, AI848451, EHSH1, Ese1, INTERSECTIN, Intersectin 1, intersectin 1 (SH3 domain protein 1A), ITSN, LOC100911851, SH3D1A, SH3 domain protein-1A, SH3P17 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Itsn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Coiled-coil domain-containing protein 3
- Arginine and glutamate-rich 1
- RIB43A
- coiled-coil domain
- Type III secretion protein YscO
- Chromatin assembly factor 1 complex p150 subunit, N-terminal
- ClassIIa_HDAC_Gln-rich-N
- PH domain
- iSH2_PI3K_IA_R
- Dbl homology domain
- Centrosomal protein of 63 kDa
- C2 domain
- Cortexillin I, coiled coil
- Crescentin protein
- RNase Y N-terminal region
- Ezrin/radixin/moesin, alpha-helical domain
- Hyaluronan mediated motility receptor N-terminal
- EF-hand domain pair
- Intersectin and clathrin adaptor AP2 binding region
- EFh
- protein binding
- Pleckstrin homology-like domain
- Calcium binding and coiled-coil domain (CALCOCO1) like
- TolA protein
- RhoGEF domain
- Src Homology 3 domain superfamily
- Domain of unknown function (DUF4659)
- RhoGEF
- Domain of unknown function (DUF4686)
- flagellar export protein FliJ
- Apg6 coiled-coil region
- MAP7 (E-MAP-115) family
- Trichohyalin-plectin-homology domain
- guanyl-nucleotide exchange factor
- kinase activator
- Eps15 homology domain
- Protein kinase C conserved region 2 (CalB)
- Pleckstrin homology domain
- Cytoskeletal-regulatory complex EF hand
- Coiled-coil domain-containing protein 66
Pathways
Biological processes and signaling networks where the Itsn1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hereditary disorder
- neurodevelopmental disorder
- diabetic nephropathy
- schizophrenia
- pulmonary hypertensive arterial disease
- growth failure
- diabetic retinopathy
- Down syndrome
- autosomal dominant mental retardation type 1
role in cell
- apoptosis
- growth
- activation in
- proliferation
- phosphorylation in
- migration
- adhesion
- colony formation
- rearrangement
- disorganization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- synaptic plasma membrane fractions
- membrane fraction
- presynaptic active zone
- glutaminergic synapse
- exocytotic site
- intracellular membrane-bounded organelle
- cytoskeleton
- cell periphery
- cellular membrane
- actin cytoskeleton
- Plasma Membrane
- vesicles
- cytosol
- nuclear envelope
- dendritic spines
- synaptic vesicles
- synaptosomes
- endocytotic vesicle
- clathrin-coated pits
- perikaryon
- axon terminals
- clathrin-coated vesicles
- lamellipodia
- apical processes
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Itsn1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of small GTPase mediated signal transduction
- protein transport
- protein localization
- endosomal transport
- exocytosis
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- nuclear envelope
- cytoplasm
- coated pit
- cytosol
- recycling endosome
- neuron projection
- plasma membrane
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- proline-rich region binding
- protein binding
- calcium ion binding
- guanyl-nucleotide exchange factor activity
- binding, bridging