Sqle Gene Summary [Rat]
Enables squalene monooxygenase activity. Involved in cholesterol metabolic process and response to biphenyl. Predicted to be located in intracellular membrane-bounded organelle and membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human SQLE (squalene epoxidase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sqle |
| Official Name | squalene epoxidase [Source:RGD Symbol;Acc:3755] |
| Ensembl ID | ENSRNOG00000009550 |
| Bio databases IDs | |
| Aliases | squalene epoxidase |
| Synonyms | squalene 2, 3-epoxidase, squalene epoxidase, Squalene Monooxygenase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sqle often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- FAD binding
- FAD binding domain
- Squalene epoxidase
- SM-N100 region
- FAD dependent oxidoreductase
- Pyridine nucleotide-disulphide oxidoreductase
- enzyme
- squalene monooxygenase
- protein binding
- ubiquinone biosynthesis monooxygenase COQ6
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection
- multiple sclerosis
- rheumatoid arthritis
- neoplasia
- epithelial cancer
- experimental autoimmune encephalomyelitis
- liver neoplasia
- bladder cancer
- breast cancer
- hypersensitive reaction
role in cell
- expression in
- proliferation
- accumulation in
- phosphorylation in
- quantity
- apoptosis
- survival
- morphology
- cell viability
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cellular membrane
- endoplasmic reticulum membrane
- microsome
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sqle gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cholesterol metabolic process
- regulation of cell proliferation
- sterol biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- intracellular membrane-bounded organelle
- membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- FAD binding
- protein binding
- squalene monooxygenase activity