Cybrd1 Gene Summary [Rat]
Predicted to enable identical protein binding activity; transmembrane ascorbate ferrireductase activity; and transmembrane monodehydroascorbate reductase activity. Predicted to be involved in ascorbate homeostasis; intracellular iron ion homeostasis; and multicellular organismal-level iron ion homeostasis. Predicted to act upstream of or within response to iron ion. Predicted to be located in apical plasma membrane and brush border membrane. Predicted to be active in lysosomal membrane. Orthologous to human CYBRD1 (cytochrome b reductase 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cybrd1 |
| Official Name | cytochrome b reductase 1 [Source:RGD Symbol;Acc:1305740] |
| Ensembl ID | ENSRNOG00000009620 |
| Bio databases IDs | |
| Aliases | cytochrome b reductase 1 |
| Synonyms | 2210407P13Rik, CYB561A2, cytochrome b reductase 1, DCYTB, FLJ23462, FRRS3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cybrd1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- metal ion oxidising oxidoreductase
- oxidoreductase
- oxidoreduction-driven active transporter
- Cytochrome_b_N
- enzyme
- protein binding
- identical protein binding
Pathways
Biological processes and signaling networks where the Cybrd1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atrial fibrillation
- insulin resistance
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- obesity
- chronic obstructive pulmonary disease
regulates
- heavy metal
- Ferric Reductase
- iron ion
role in cell
- homeostasis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Plasma Membrane
- vesicles
- apical membrane
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cybrd1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular iron ion homeostasis
- multicellular organismal iron ion homeostasis
- transmembrane transport
- response to iron ion
- iron assimilation by reduction and transport
Cellular Component
Where in the cell the gene product is active
- brush border membrane
- extracellular vesicular exosome
- membrane
- lysosomal membrane
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- oxidoreductase activity, oxidizing metal ions
- identical protein binding
- protein binding
- oxidoreductase activity
- metal ion binding