Slco1c1 Gene Summary [Rat]
Enables bile acid transmembrane transporter activity. Involved in bile acid and bile salt transport. Located in basolateral plasma membrane. Biomarker of primary biliary cholangitis. Orthologous to human SLCO1C1 (solute carrier organic anion transporter family member 1C1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slco1c1 |
| Official Name | solute carrier organic anion transporter family, member 1c1 [Source:RGD Symbol;Acc:628660] |
| Ensembl ID | ENSRNOG00000009740 |
| Bio databases IDs | |
| Aliases | solute carrier organic anion transporter family, member 1c1 |
| Synonyms | BAST1, Bsat1, OATP1, OATP-14, OATP1C1, Oatp2, OATP-F, OATP-RP5, OAT-RP-5, SLC21A14, solute carrier organic anion transporter family member 1C1, solute carrier organic anion transporter family, member 1c1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slco1c1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Organic Anion Transporter Polypeptide (OATP) family
- Major Facilitator Superfamily
- sodium-independent organic anion transporter
- bile acid transporter
- thyroid hormone transporter
- KAZAL_FS
- organic anion transporter
- transporter
Pathways
Biological processes and signaling networks where the Slco1c1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- intrahepatic cholestasis of pregnancy
- hypomyelination
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- lateral cell surfaces
- apical cell surfaces
- basolateral membrane
- basal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slco1c1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ion transport
- transmembrane transport
- sodium-independent organic anion transport
- positive regulation of thyroid hormone generation
- thyroid hormone transport
- bile acid and bile salt transport
Cellular Component
Where in the cell the gene product is active
- basolateral plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- bile acid transmembrane transporter activity
- thyroid hormone transmembrane transporter activity
- organic anion transmembrane transporter activity
- sodium-independent organic anion transmembrane transporter activity