Tspan2 Gene Summary [Rat]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

Details

Type
Protein Coding
Official Symbol
Tspan2
Official Name
tetraspanin 2 [Source:RGD Symbol;Acc:620982]
Ensembl ID
ENSRNOG00000023338
Bio databases IDs NCBI: 64521 Ensembl: ENSRNOG00000023338
Aliases tetraspanin 2
Synonyms 6330415F13Rik, B230119D02Rik, NET3, tetraspanin 2, TSN2
Species
Rat, Rattus norvegicus
OrthologiesHumanMouse

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tspan2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • tetraspanin_LEL
  • protein binding
  • Tetraspanin family

Pathways

Biological processes and signaling networks where the Tspan2 gene in rat plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • diabetic nephropathy
  • non-insulin-dependent diabetes mellitus
  • schizophrenia
  • demyelination
  • astrocytosis
  • paralysis
  • X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia
  • microgliosis
  • preeclampsia
  • kyphosis
regulated by
regulates
role in cell
  • apoptosis
  • formation
  • activation in
  • degeneration
  • development
  • differentiation
  • myelination
  • upregulation in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Extracellular Space
  • cellular membrane
  • Plasma Membrane
  • nucleoplasm
  • myelin sheath

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the rat Tspan2 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • oligodendrocyte differentiation
  • astrocyte development
  • inflammatory response
  • myelination
  • microglia development

Cellular Component

Where in the cell the gene product is active
  • myelin sheath
  • membrane
  • plasma membrane
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • protein binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.