Vangl1 Gene Summary [Rat]
Predicted to act upstream of or within mucociliary clearance and pigmentation. Predicted to be located in lateral plasma membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in caudal regression syndrome and neural tube defect. Orthologous to human VANGL1 (VANGL planar cell polarity protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vangl1 |
| Official Name | VANGL planar cell polarity protein 1 [Source:RGD Symbol;Acc:1597324] |
| Ensembl ID | ENSRNOG00000016477 |
| Bio databases IDs | |
| Aliases | VANGL planar cell polarity protein 1 |
| Synonyms | KITENIN, LOC683383, LPP2, STB2, Stbm, STBM2, VANGL, VANGL planar cell polarity 1, VANGL planar cell polarity protein 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Vangl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Strabismus protein
- cytoplasmic domain
- protein binding
Pathways
Biological processes and signaling networks where the Vangl1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neural tube defect
- caudal dysplasia sequence
role in cell
- expression in
- growth
- binding
- tumorigenicity
- binding in
- invasion by
- 5-fluorouracil resistance
- invasion
- healing
- oxaliplatin resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell periphery
- cellular membrane
- Plasma Membrane
- lateral plasma membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Vangl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- pigmentation
- Wnt receptor signaling pathway, planar cell polarity pathway
Cellular Component
Where in the cell the gene product is active
- lateral plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding