Plek2 Gene Summary [Rat]
Predicted to enable phosphatidylinositol-3,4-bisphosphate binding activity; phosphatidylinositol-3,5-bisphosphate binding activity; and phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in actin cytoskeleton organization and positive regulation of plasma membrane bounded cell projection assembly. Predicted to act upstream of or within positive regulation of cell projection organization. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human PLEK2 (pleckstrin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Plek2 |
| Official Name | pleckstrin 2 [Source:RGD Symbol;Acc:1305786] |
| Ensembl ID | ENSRNOG00000010098 |
| Bio databases IDs | |
| Aliases | pleckstrin 2 |
| Synonyms | pleckstrin 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Plek2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
- DEP
- binding protein
- PH domain
- Pleckstrin homology-like domain
- phosphatidylinositol binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- major depression
- anemia
- atherosclerosis
- organismal death
- metastasis
- lung adenocarcinoma
- lung adenocarcinoma formation
- colon epithelial cancer
- hallucinations
- colon carcinoma
role in cell
- proliferation
- number
- migration
- phosphorylation in
- autophagy in
- expression in
- differentiation
- cisplatin resistance
- invasion by
- migratory capacity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Plek2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- actin cytoskeleton organization
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- cytoplasm
- plasma membrane
- lamellipodium membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-3,5-bisphosphate binding
- phosphatidylinositol-3-phosphate binding
- phosphatidylinositol-3,4-bisphosphate binding