Rin2 Gene Summary [Rat]
Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in positive regulation of endothelial cell migration; positive regulation of endothelial cell-matrix adhesion via fibronectin; and positive regulation of vasculogenesis. Predicted to be active in cytosol and endocytic vesicle. Orthologous to human RIN2 (Ras and Rab interactor 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rin2 |
| Official Name | Ras and Rab interactor 2 [Source:RGD Symbol;Acc:1305873] |
| Ensembl ID | ENSRNOG00000010131 |
| Bio databases IDs | |
| Aliases | Ras and Rab interactor 2 |
| Synonyms | 2010003K16Rik, 4632403N06Rik, MACS, RAB5 interacting protein 2, Ras and Rab interactor 2, RASSF4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rin2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rin homology domain
- VPS9p domain
- Ras-binding domain
- Ubl1_cv_Nsp3_N-like
- Vacuolar sorting protein 9 (VPS9) domain
- Src homology 2 (SH2) domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- bipolar disorder
- macrocephaly, alopecia, cutis laxa, and scoliosis
- cerebral atherosclerosis
- breast carcinoma
- oral squamous cell carcinoma
- squamous cell cancer of the oral cavity
regulates
role in cell
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- anchoring junction
- cell-cell adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rin2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- small GTPase mediated signal transduction
- positive regulation of vasculogenesis
- endocytosis
- positive regulation of endothelial cell migration
Cellular Component
Where in the cell the gene product is active
- endocytic vesicle
- cytosol
Molecular Function
What the gene product does at the molecular level
- guanyl-nucleotide exchange factor activity
- GTPase activator activity
- small GTPase binding
- GTPase regulator activity