Eif2s3 Gene Summary [Rat]
Predicted to enable methionyl-initiator methionine tRNA binding activity; translation factor activity, RNA binding; and translation initiation factor activity. Predicted to contribute to tRNA binding activity. Predicted to be involved in formation of translation preinitiation complex. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic translation initiation factor 2 complex. Predicted to be active in synapse. Human ortholog(s) of this gene implicated in MEHMO syndrome. Orthologous to several human genes including EIF2S3 (eukaryotic translation initiation factor 2 subunit gamma). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Eif2s3 |
| Official Name | eukaryotic translation initiation factor 2 subunit gamma [Source:RGD Symbol;Acc:1561279] |
| Ensembl ID | ENSRNOG00000060793 |
| Bio databases IDs | |
| Aliases | eukaryotic translation initiation factor 2 subunit gamma |
| Synonyms | EIF2, EIF2G, eIF-2gA, EIF2gamma, eIF-2-gamma X, eIF2gX, Eif2s3x, Eif2 γ, eIF-2-γ X, Eukaryotic translation initiation factor 2, subunit 3, eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked, eukaryotic translation initiation factor 2 subunit gamma, eukaryotic translation initiation factor 2 subunit γ, IF2G, MEHMO, MRXSBRK, PP42 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Eif2s3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tRNA binding
- nucleic acid binding translation factor
- GTPase
- guanine nucleotide binding domain
- protein binding
- Elongation factor Tu domain 2
- translation regulator
- Initiation factor eIF2 gamma, C terminal
- translation initiation factor 2 subunit gamma
- Domain III of Elongation factor (EF) Tu (EF-TU) and related proteins
- Domain II of Elongation factor Tu (EF-Tu)-like proteins
- translation initiation factor
- Elongation factor Tu GTP binding domain
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Eif2s3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-small cell lung cancer
- non-insulin-dependent diabetes mellitus
- MEHMO syndrome
- prostate cancer
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- Turner syndrome
- atypical MEHMO syndrome
- Klinefelter syndrome
role in cell
- processing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Eif2s3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- formation of translation preinitiation complex
- cytoplasmic translational initiation
- translational initiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- cytosol
- eukaryotic translation initiation factor 2 complex
Molecular Function
What the gene product does at the molecular level
- GTP binding
- translation initiation factor activity
- protein binding
- GTPase activity
- cadherin binding
- translation factor activity, nucleic acid binding
- tRNA binding