Hspb2 Gene Summary [Rat]
The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The protein is expressed preferentially in the heart and skeletal muscle. This protein regulates Myotonic Dystrophy Protein Kinase, which plays an important role in maintenance of muscle structure and function. [provided by RefSeq, Dec 2012]
Details
| Type | Protein Coding |
| Official Symbol | Hspb2 |
| Official Name | heat shock protein family B (small) member 2 [Source:RGD Symbol;Acc:70914] |
| Ensembl ID | ENSRNOG00000010402 |
| Bio databases IDs | |
| Aliases | heat shock protein family B (small) member 2 |
| Synonyms | 2810021G24Rik, heat shock protein 2, heat shock protein family B (small) member 2, Hs.78846, HSP27, LOH11CR1K, MKBP |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hspb2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alpha-crystallin domain
- alpha-crystallin Hsps/p23-like
- Hsp20/alpha crystallin family
- protein binding
- enzyme activator activity
Pathways
Biological processes and signaling networks where the Hspb2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- rotator cuff injury
- systemic lupus erythematosus
- non-insulin-dependent diabetes mellitus
- Alzheimer disease
- idiopathic scoliosis
- pemphigus foliaceus
- preeclampsia
role in cell
- apoptosis
- formation in
- production in
- oxidative stress response
- aggregation in
- formation
- development
- fibrillogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- soluble fraction
- cilia
- Nucleus
- cytosol
- neuromuscular junctions
- Z line
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hspb2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to heat
- negative regulation of apoptotic process
- protein refolding
- response to unfolded protein
- somatic muscle development
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- enzyme activator activity
- unfolded protein binding
- structural constituent of eye lens