Cyp39a1 Gene Summary [Rat]
Predicted to enable oxysterol 7-alpha-hydroxylase activity. Predicted to be involved in bile acid biosynthetic process and cholesterol homeostasis. Predicted to act upstream of or within cholesterol catabolic process. Predicted to be located in endoplasmic reticulum membrane. Orthologous to human CYP39A1 (cytochrome P450 family 39 subfamily A member 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cyp39a1 |
| Official Name | cytochrome P450, family 39, subfamily a, polypeptide 1 [Source:RGD Symbol;Acc:1307471] |
| Ensembl ID | ENSRNOG00000010519 |
| Bio databases IDs | |
| Aliases | cytochrome P450, family 39, subfamily a, polypeptide 1 |
| Synonyms | cytochrome P450 family 39 subfamily A member 1, cytochrome P450, family 39, subfamily a, polypeptide 1, mCYP39A1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cyp39a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- oxysterol 7-alpha-hydroxylase
- cytochrome P450 (CYP) superfamily
- Cytochrome P450
- steroid 7-alpha-hydroxylase
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
- Alzheimer disease
- epithelial cancer
- hepatocellular carcinoma
- liver cancer
- hepatitis B virus-related hepatocellular carcinoma
regulates
- cholesterol
- 24-hydroxycholesterol
- bile acid
- sterol
role in cell
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cyp39a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cholesterol catabolic process
- digestion
- bile acid biosynthetic process
- cholesterol homeostasis
- sterol metabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- intracellular membrane-bounded organelle
Molecular Function
What the gene product does at the molecular level
- 24-hydroxycholesterol 7alpha-hydroxylase activity
- iron ion binding
- oxysterol 7-alpha-hydroxylase activity
- steroid 7-alpha-hydroxylase activity
- heme binding