Aldh5a1 Gene Summary [Rat]
Enables NAD binding activity; carboxylic acid binding activity; and succinate-semialdehyde dehydrogenase (NAD+) activity. Involved in succinate metabolic process. Predicted to be located in synapse. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in succinic semialdehyde dehydrogenase deficiency. Orthologous to human ALDH5A1 (aldehyde dehydrogenase 5 family member A1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Aldh5a1 |
| Official Name | aldehyde dehydrogenase 5 family, member A1 [Source:RGD Symbol;Acc:621422] |
| Ensembl ID | ENSRNOG00000023538 |
| Bio databases IDs | |
| Aliases | aldehyde dehydrogenase 5 family, member A1 |
| Synonyms | 6330403E24RIK, Ahd-1, aldehyde dehydrogenase 5 family member A1, aldehyde dehydrogenase 5 family, member A1, aldhehyde dehydrogenase family 5, subfamily A1, D630032B01RIK, SSADH, SSDH, Ssdh1, Succinate Semialdehyde Dehydrogenase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Aldh5a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Aldehyde dehydrogenase family
- NAD or NADH binding
- binding protein
- succinate-semialdehyde dehydrogenase
- aldehyde dehydrogenase, Rv0768 family
- enzyme
- identical protein binding
- delta-1-pyrroline-5-carboxylate dehydrogenase, group 2, putative
- delta-1-pyrroline-5-carboxylate dehydrogenase (PutA C-terminal domain)
- NAD(P)+-dependent aldehyde dehydrogenase superfamily
Pathways
Biological processes and signaling networks where the Aldh5a1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- stroke
- asthma
- epilepsy
- Alzheimer disease
- lymphoma
- anaplastic astrocytoma
- simple absence seizure
- alcohol withdrawal syndrome
- succinic semialdehyde dehydrogenase deficiency
role in cell
- expression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Aldh5a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glutamate metabolic process
- central nervous system development
- gamma-aminobutyric acid catabolic process
- post-embryonic development
- synaptic transmission, GABAergic
- succinate metabolic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
- synapse
Molecular Function
What the gene product does at the molecular level
- succinate-semialdehyde dehydrogenase (NAD+) activity
- identical protein binding