Cyp7b1 Gene Summary [Rat]
Predicted to enable oxysterol 7-alpha-hydroxylase activity. Involved in several processes, including circadian rhythm; memory; and response to cAMP. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital bile acid synthesis defect 3 and hereditary spastic paraplegia 5A. Orthologous to human CYP7B1 (cytochrome P450 family 7 subfamily B member 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cyp7b1 |
| Official Name | cytochrome P450 family 7 subfamily B member 1 [Source:RGD Symbol;Acc:2483] |
| Ensembl ID | ENSRNOG00000009730 |
| Bio databases IDs | |
| Aliases | cytochrome P450 family 7 subfamily B member 1 |
| Synonyms | CBAS3, Cholesterol 7 beta-hydroxylase, Cholesterol 7 β-hydroxylase, CP7B, cytochrome P450 family 7 subfamily B member 1, cytochrome P450, family 7, subfamily b, polypeptide 1, D3Ertd552e, hct-1, Oxysterol 7alpha-Hydroxylase, SPG5A, SPG5B |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cyp7b1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- oxysterol 7-alpha-hydroxylase
- cytochrome P450 (CYP) superfamily
- Cytochrome P450
- enzyme
- protein binding
- NADH2 or NADPH2 1 atom incorporation:oxygen oxidoreductase
Pathways
Biological processes and signaling networks where the Cyp7b1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- human immunodeficiency virus I infection
- Alzheimer disease
- depressive disorder
- liver failure
- spastic paraplegia
- osteoarthritis
- congenital bile acid synthesis defect type 3
- hereditary disorder
- hereditary spastic paraplegia 5A
role in cell
- proliferation
- response
- chemotaxis by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- microsome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cyp7b1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- prostate gland epithelium morphogenesis
- epithelial cell proliferation
- cholesterol metabolic process
- negative regulation of intracellular estrogen receptor signaling pathway
- bile acid biosynthetic process
- sterol metabolic process
- positive regulation of epithelial cell proliferation
- cholesterol homeostasis
- intracellular estrogen receptor signaling pathway
- B cell chemotaxis
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
Molecular Function
What the gene product does at the molecular level
- 24-hydroxycholesterol 7alpha-hydroxylase activity
- iron ion binding
- oxysterol 7-alpha-hydroxylase activity
- 25-hydroxycholesterol 7alpha-hydroxylase activity
- heme binding