Smarcd2 Gene Summary [Rat]
Predicted to enable transcription coregulator activity. Predicted to be involved in nucleosome disassembly and regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be part of SWI/SNF complex. Predicted to be active in nucleus. Orthologous to human SMARCD2 (SWI/SNF related BAF chromatin remodeling complex subunit D2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Smarcd2 |
| Official Name | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 [Source:RGD Symbol;Acc:69289] |
| Ensembl ID | ENSRNOG00000010557 |
| Bio databases IDs | |
| Aliases | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 |
| Synonyms | BAF60B, CRACD2, PRO2451, Rsc6p, SGD2, SWI/SNF related BAF chromatin remodeling complex subunit D2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Smarcd2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SWIB/MDM2 domain
- transcription regulator
- protein binding
- SWIB/MDM2 domain family
- SWI complex, BAF60b domains
Pathways
Biological processes and signaling networks where the Smarcd2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- specific granule deficiency 2
- renal clear cell adenocarcinoma
- renal clear cell cancer
- chronic lymphocytic leukemia
regulates
role in cell
- expression in
- disassembly
- remodeling
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Smarcd2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of mitotic metaphase/anaphase transition
- positive regulation of myoblast differentiation
- positive regulation of cell differentiation
- regulation of nucleotide-excision repair
- nucleosome disassembly
- regulation of transcription from RNA polymerase II promoter
- chromatin remodeling
- positive regulation of transcription, DNA-dependent
- positive regulation of T cell differentiation
- regulation of G1/S transition of mitotic cell cycle
- positive regulation of double-strand break repair
- regulation of G0 to G1 transition
Cellular Component
Where in the cell the gene product is active
- SWI/SNF complex
- nucleus
- nuclear matrix
- macromolecular complex
- brahma complex
- kinetochore
- RSC complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription cofactor activity
- transcription coactivator activity
- nucleosomal DNA binding