Hpgd Gene Summary [Rat]
Enables 15-hydroxyprostaglandin dehydrogenase (NAD+) activity and identical protein binding activity. Involved in several processes, including positive regulation of vascular associated smooth muscle cell proliferation; prostaglandin metabolic process; and thrombin-activated receptor signaling pathway. Located in extracellular space. Used to study carcinoma. Biomarker of peptic ulcer disease. Human ortholog(s) of this gene implicated in colon carcinoma and primary hypertrophic osteoarthropathy. Orthologous to human HPGD (15-hydroxyprostaglandin dehydrogenase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hpgd |
| Official Name | 15-hydroxyprostaglandin dehydrogenase [Source:RGD Symbol;Acc:620087] |
| Ensembl ID | ENSRNOG00000010610 |
| Bio databases IDs | |
| Aliases | 15-hydroxyprostaglandin dehydrogenase |
| Synonyms | 15-HYDROXY PROSTAGLANDIN DEHYDROGENASE, 15-PGDH, Hydroxyprostaglandin Dehydrogenase, hydroxyprostaglandin dehydrogenase 15 (NAD), PGDH, PGDH1, PHOAR1, SDR36C1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hpgd often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- pteridine reductase
- 15-hydroxyprostaglandin dehydrogenase (NAD)
- enzyme
- Enoyl-(Acyl carrier protein) reductase
- identical protein binding
- polyketide synthase keto reductase domain
- NAD or NADH binding
- sepiapterin reductase
- binding protein
- prostaglandin E receptor
- acetoacetyl-CoA reductase
- CH-OH group:NAD or NADP oxidoreductase
- short chain dehydrogenase
Pathways
Biological processes and signaling networks where the Hpgd gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- non-small cell lung cancer
- non-small cell lung carcinoma
- autosomal recessive primary hypertrophic osteoarthropathy type 1
- Crohn disease
- ulcerative colitis
- neoplasia
- hepatitis B virus-related hepatocellular carcinoma
- liver cancer
- diabetic nephropathy
role in cell
- expression in
- production in
- apoptosis
- proliferation
- replication in
- growth
- colony formation
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- Nucleus
- cytosol
- basolateral membrane
- nucleoplasm
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hpgd gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cell cycle
- transforming growth factor beta receptor signaling pathway
- ductus arteriosus closure
- female pregnancy
- prostaglandin metabolic process
- parturition
- response to ethanol
- thrombin receptor signaling pathway
- kidney development
- lipoxygenase pathway
- positive regulation of apoptotic process
- ovulation
- response to estradiol stimulus
- response to lipopolysaccharide
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- cytosol
- basolateral plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- 15-hydroxyprostaglandin dehydrogenase (NAD+) activity
- identical protein binding
- oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
- prostaglandin E receptor activity
- NAD binding
- NAD+ binding