Fosb Gene Summary [Rat]
Enables DNA-binding transcription factor activity; double-stranded DNA binding activity; and sequence-specific DNA binding activity. Involved in several processes, including behavioral response to cocaine; response to corticosterone; and response to progesterone. Located in cytosol and nucleus. Used to study heroin dependence and morphine dependence. Biomarker of several diseases, including alcohol dependence; alcohol use disorder; amphetamine abuse; cocaine abuse; and drug dependence (multiple). Orthologous to human FOSB (FosB proto-oncogene, AP-1 transcription factor subunit). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fosb |
| Official Name | FosB proto-oncogene, AP-1 transcription factor subunit [Source:RGD Symbol;Acc:1308198] |
| Ensembl ID | ENSRNOG00000046667 |
| Bio databases IDs | |
| Aliases | FosB proto-oncogene, AP-1 transcription factor subunit |
| Synonyms | AP-1, FBJ osteosarcoma oncogene B, FosB proto-oncogene, AP-1 transcription factor subunit, fra-2, G0S3, GOS3, GOSB |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fosb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- nucleic acid binding
- double-stranded DNA binding
- transcription activation domain
- protein binding
- sequence-specific DNA binding
- bZIP
- transcription factor activity
- basic region leucin zipper
- DNA binding
Pathways
Biological processes and signaling networks where the Fosb gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atherosclerosis
- breast cancer
- hepatocellular carcinoma
- epithelial cancer
- non-small cell lung cancer
- cervical cancer
- cognitive impairment
- lung adenocarcinoma
- small cell lung cancer
- adenoma formation
role in cell
- activation in
- proliferation
- apoptosis
- expression in
- growth
- differentiation
- quantity
- motility
- transformation
- radioresistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- intracellular membrane-bounded organelle
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fosb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to progesterone stimulus
- female pregnancy
- transcription from RNA polymerase II promoter
- response to cAMP
- response to morphine
- response to xenobiotic stimulus
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
- response to mechanical stimulus
- negative regulation of transcription from RNA polymerase II promoter
- response to ethanol
- response to corticosterone stimulus
- behavioral response to cocaine
- cellular response to calcium ion
- response to amphetamine
- cellular response to hormone stimulus
Cellular Component
Where in the cell the gene product is active
- nucleus
- intracellular membrane-bounded organelle
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity