Ube3c Gene Summary [Rat]
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein K29-linked ubiquitination; protein K48-linked ubiquitination; and ubiquitin-dependent protein catabolic process. Orthologous to human UBE3C (ubiquitin protein ligase E3C). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ube3c |
| Official Name | ubiquitin protein ligase E3C [Source:RGD Symbol;Acc:1559986] |
| Ensembl ID | ENSRNOG00000010702 |
| Bio databases IDs | |
| Aliases | ubiquitin protein ligase E3C |
| Synonyms | HECTH2, KIAA0010, KIAA10, mKIAA0010, NDSMBA, NEDSMBA, RAUL, RGD1559986, Ubiquitin Protein Isopeptide Ligase E3, ubiquitin protein ligase E3C |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ube3c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- HECTc
- Calmodulin-binding motif
- ubiquitin protein ligase activity
- Domain Homologous to E6-AP Carboxyl Terminus with
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- neoplasia
- diabetes mellitus
- lung squamous cell carcinoma
- squamous cell lung cancer
- neurodevelopmental disorder with absent speech and movement and behavioral abnormalities
- headache
- diabetic neuropathy
- metabolic syndrome X
- diabetic retinopathy
role in cell
- expression in
- degradation in
- replication in
- radioresistance
- tanespimycin sensitivity
- radiosensitivity
- transcription in
- endoplasmic reticulum-associated degradation in
- K48 polyubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ube3c gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein K48-linked ubiquitination
- protein K29-linked ubiquitination
- protein polyubiquitination
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- proteasome complex
Molecular Function
What the gene product does at the molecular level
- protein binding